anti-thyroid drugs-related myopathy: is carbimazole the real culprit?

Anti-Thyroid Drugs-Related Myopathy: Is Carbimazole the Real Culprit?

INTRODUCTION Anti-thyroid drugs (ATDs)-related myopathy is rarely reported in literature, but once developed, it can cause significant morbidity to patient. CASE PRESENTATION A 28-year old Chinese female was treated with carbimazole (CMZ) for Graves' disease with hyperthyroidism. Two weeks later, she developed myalgia and proximal muscle weakness. Investigations showed evidence of myopathy. C...

Thyroid function tests during carbimazole therapy.

Changes in plasma thyroxine (T4), triiodothyronine (T3), free thyroxine index (FT4I) and thyroid stimulating hormone were studied in 100 patients with Graves' disease treated with carbimazole. During therapy plasma T3 concentrations were disproportionately high compared to those of T4, the T4 : T3 ratio was low, and many patients were clinically euthyroid with a normal plasma T3 but low T4 conc...

Myopathy, Drugs, and Mitochondria

Where is the culprit?

Address for Correspondence: Dr. Şükrü Akyüz, Tıbbıye Cad. No: 23, Siyami Ersek Göğüs ve Kalp Damar Cerrahisi Eğitim ve Araştırma Hastanesi, İstanbul-Türkiye Phone: +90 532 340 74 72 Fax: +90 216 444 52 57 E-mail: [email protected] Available Online Date: 09.04.2015 ©Copyright 2015 by Turkish Society of Cardiology Available online at www.anatoljcardiol.com DOI:10.5152/akd.2015.6241 Diagnosti...

Propylthiouracil, and methimazole, and carbimazole-related hepatotoxicity.

INTRODUCTION Propylthiouracil (PTU) has been used for the treatment of hyperthyroidism since the 1940s, but over the years reports of significant hepatotoxicity have come forth, particularly in children. This led to a black box warning being issued by the US FDA in 2009, followed by a similar warning by the European Medicines Agency and the United Kingdom Medicines and Healthcare Regulatory Age...

Antithyroid drugs and congenital heart defects: ventricular septal defect is part of the methimazole/carbimazole embryopathy.

Short title: Antithyroid drugs and birth defects